abstract：AIM AND SCOPE:To determine the acute effects of increased intra-abdominal pressure (IAP) on the biochemistry, morphology, and contractility of the isolated terminal ileum of rats. BACKGROUND:Laparoscopic procedures are used clinically in diagnostic and treatment modalities and experimentally as a model of ischemia-rep...

journal_title：Pharmacological research

authors： Unsal MA,Imamoglu M,Kadioglu M,Aydin S,Ulku C,Kesim M,Alver A,Kalyoncu NI,Yaris E,Bozkaya H

更新日期：2006-02-01 00:00:00

abstract：:Cosmetics are largely diffused substances topically applied to wash, to perfume or to improve the look, nevertheless the number of reported adverse reactions is very low, probably because of underreporting. This could be due to self-diagnosis and self-medication that is common in the presence of not severe reactions. ...

journal_title：Pharmacological research

authors： Di Giovanni C,Arcoraci V,Gambardella L,Sautebin L

更新日期：2006-01-01 00:00:00

abstract：:As the capacity of the endogenous antioxidative system is limited, pharmacological treatment with antioxidants may help to protect neuronal tissue against increased amount of reactive oxygen species produced during oxidative stress. We attempted to improve resistance of rat hippocampal slices exposed to ischaemia in v...

journal_title：Pharmacological research

authors： Gáspárová Z,Stolc S,Snirc V

更新日期：2006-01-01 00:00:00

abstract：:Epidemiological studies suggest that diets with a high intake of vegetables and fruits may reduce the incidence of degenerative disorders including Alzheimer's disease. Berries are some of the popular fruits consumed worldwide. They are considered to be rich in anthocyanin pigments, a group belonging to the flavonoids...

journal_title：Pharmacological research

authors： Ramirez MR,Izquierdo I,do Carmo Bassols Raseira M,Zuanazzi JA,Barros D,Henriques AT

更新日期：2005-12-01 00:00:00

abstract：:We aimed to examine the effects of KTO-7924 (beta3-adrenoceptor agonist) on lipid metabolism and mRNA expressions in retroperitoneal white adipose tissue (RP WAT) in obese (fa/fa) Zucker rats using DNA microarray. Oral KTO-7924 for 28 days significantly decreased RP WAT weight, plasma triglyceride, free fatty acid, an...

journal_title：Pharmacological research

authors： Oana F,Homma T,Takeda H,Matsuzawa A,Akahane S,Isaji M,Akahane M

更新日期：2005-11-01 00:00:00

abstract：:Leukocyte arylsulphatase A (AS-A) was shown to be significantly high in newly-diagnosed breast cancer patients. Previous reports imply a connection between serum interleukin-6 (IL-6) and breast cancer, possibly through a modulation of enzymes involved in estrogen synthesis. Abnormal distribution of heparan sulphate pr...

journal_title：Pharmacological research

authors： Oner-Iyidoğan Y,Oner P,Koçak H,Lama A,Gürdöl F,Bekpinar S,Unur N,Ozbek-Kir Z

更新日期：2005-10-01 00:00:00

abstract：:The aim of the present pilot study was to characterise the renal elimination of betalains after consumption of red beet juice (RBJ). Six healthy, non-smoking female volunteers were given a single oral dose of either 500 mL of a commercial RBJ containing 362.7 mg of betalains and 500 mL of tap water, respectively, in a...

journal_title：Pharmacological research

authors： Frank T,Stintzing FC,Carle R,Bitsch I,Quaas D,Strass G,Bitsch R,Netzel M

更新日期：2005-10-01 00:00:00

abstract：:Our preliminary data suggested that 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene [Viale M, Ottone M, Chiavarina B, Mariggiò MA, Prevosto C, Dell'Erba C, et al. Preliminary evaluation in vitro of the inhibition of cell proliferation, cytotoxicity and induction of apoptosis by 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadi...

journal_title：Pharmacological research

authors： Dell'Erba C,Chiavarina B,Fenoglio C,Petrillo G,Cordazzo C,Boncompagni E,Spinelli D,Ognio E,Aiello C,Mariggiò MA,Viale M

更新日期：2005-09-01 00:00:00

abstract：:The effect of fluvoxamine (FLV) a selective serotonin reuptake inhibitor agent was studied on ouabain-induced arrhythmia in spontaneously beating isolated guinea-pig atria. FLV (8-64 microM) caused a dose-dependent decrease in the rate of contractions (7-52%) and in the contractile force (11-57%). Ouabain alone (2 mic...

journal_title：Pharmacological research

authors： Pousti A,Deemyad T,Brumand K,Bakhtiarian A

更新日期：2005-08-01 00:00:00

abstract：:Over the past decade, poly(ADP-ribosyl)ation has emerged as a crucial event in the pathogenesis of ischemic stroke. A large body of evidence unambiguously demonstrates that activity of poly(ADP-ribose) polymerase-1 (PARP-1) significantly increases during brain ischemia, and that inhibition of this enzymatic activity a...

journal_title：Pharmacological research

authors： Chiarugi A

更新日期：2005-07-01 00:00:00

abstract：:Heparin-binding protein (HBP; CAP37/azurocidin) is secreted from neutrophil leukocytes early during inflammation and plays a central role in early capillary leakage and extravasation of neutrophils. Furthermore, HBP is chemotactic towards monocytes and lymphocytes and protects against stress-induced apoptosis, e.g. in...

journal_title：Pharmacological research

authors： Lauritzen B,Lykkesfeldt J,Djurup R,Flodgaard H,Svendsen O

更新日期：2005-06-01 00:00:00

abstract：:Recent studies clearly show that there is a relationship between endotoxemia and impaired vascular responsiveness. The aim of this study was to investigate whether treatment with the new potent PARP inhibitor PJ34 could prevent the vascular hyporesponsiveness induced by lipopolysaccharide (LPS). Endotoxemia was induce...

journal_title：Pharmacological research

authors： Tasatargil A,Dalaklioglu S,Sadan G

更新日期：2005-06-01 00:00:00

abstract：:The objective of this study was to investigate the effects of 3-aminobenzamide (3-AB) on tissue damage in lung after hind limb ischemia-reperfusion (I/R), by assessing blood biochemical assay and histopathological analysis. Thirty-five adult Wistar rats were divided into five groups. After application of anaesthesia b...

journal_title：Pharmacological research

authors： Koksel O,Yildirim C,Cinel L,Tamer L,Ozdulger A,Bastürk M,Degirmenci U,Kanik A,Cinel I

更新日期：2005-05-01 00:00:00

abstract：:Anti-hypertensive agents may differently stimulate compensatory neuro-hormonal mechanisms and induce different effects on the cardiovascular remodeling and function. The combination of low doses of the two synergistic drugs may lead to a lesser activation of counter regulatory mechanisms and could provide optimal ther...

journal_title：Pharmacological research

authors： Mougenot N,Médiani O,Lechat P

更新日期：2005-04-01 00:00:00

abstract：:Limited information is available on drug-induced neuropsychiatric disorders in general practice. The spontaneous reports of both neurological and psychiatric adverse drug reactions (ADRs) collected during a 2-year period in PharmaSearch database, an Italian database recording reports of ADRs from general practitioners...

journal_title：Pharmacological research

authors： Galatti L,Giustini SE,Sessa A,Polimeni G,Salvo F,Spina E,Caputi AP

更新日期：2005-03-01 00:00:00

abstract：:It has been reported that patients with Hodgkin's disease (HD) show altered porphyrin metabolism, and suggested that the cause is the neoplastic process itself. If this is true, disease progression should be associated with higher levels of porphyrin excretion. The aim of this study was to evaluate urinary coproporphy...

journal_title：Pharmacological research

authors： Pinelli A,Mussini C,Buratti M,Parmiggiani-Venezia M,Trivulzio S

更新日期：2005-03-01 00:00:00

abstract：:The effects of ethanol (EEP) and water (WSD) extracts of propolis collected from north China on blood glucose, blood lipid and free radicals in rats with diabetes mellitus were studied. The results show that EEP and WSD led to decreased levels of blood glucose (FBG), fructosamine (FRU), malonaldehyde (MDA), nitric oxi...

journal_title：Pharmacological research

authors： Fuliang HU,Hepburn HR,Xuan H,Chen M,Daya S,Radloff SE

更新日期：2005-02-01 00:00:00

abstract：:Alzheimer's disease is the fourth largest cause of death for people over 65 years of age. Dementia of Alzheimer's type is the commonest form of dementia, the other two forms being vascular dementia and mixed dementia. At present, the therapy of Alzheimer's disease is aimed at improving both, cognitive and behavioural ...

journal_title：Pharmacological research

authors： Sonkusare SK,Kaul CL,Ramarao P

更新日期：2005-01-01 00:00:00

abstract：:Tachykinins are important in the development of pulmonary inflammation in mice but the tachykinin receptor subtype mediating this response has not been defined. To elucidate the role of tachykinin NK3-receptors on allergen-induced pulmonary inflammation, studies were performed on ovalbumin (OVA) sensitized and challen...

journal_title：Pharmacological research

authors： Kung TT,Crawley Y,Jones H,Luo B,Gilchrest H,Greenfeder S,Anthes JC,Lira S,Wiekowski M,Cook DN,Hey JA,Egan RW,Chapman RW

更新日期：2004-12-01 00:00:00

abstract：:The aim of this study was to investigate effect of antiemetics on G6PD and antioxidant enzymes. Antiemetics are currently being used to reduce or prevent nausea and vomiting in patients. This is the first study to show effect of antiemetics on glucose-6-phosphate dehydrogenase (G6PD) and antioxidant enzyme activities....

journal_title：Pharmacological research

authors： Ozmen I,Küfrevioglu OI

更新日期：2004-11-01 00:00:00

abstract：:An important aspect of brain cholinesterase function is related to enzymatic differences. The brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The two forms differ genetically, structurally and for their kinetics. Butyrylcholine is not a physi...

journal_title：Pharmacological research

authors： Giacobini E

更新日期：2004-10-01 00:00:00

abstract：:The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the alpha(2)-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected as a model of acute visceral pain. Isobolograms were constructed to assess the interactions of clon...

journal_title：Pharmacological research

authors： Miranda HF,Pinardi G

更新日期：2004-09-01 00:00:00

abstract：:The antinociceptive effect of the D(2) antagonist prochlorperazine was examined in the mouse hot-plate and abdominal constriction tests. Prochlorperazine (1-2 mg kg(-1) s.c./i.p.) produced an increase of the pain threshold in the mouse hot-plate test. The antinociception produced by prochlorperazine was prevented by t...

journal_title：Pharmacological research

authors： Ghelardini C,Galeotti N,Uslenghi C,Grazioli I,Bartolini A

更新日期：2004-09-01 00:00:00

abstract：:The effects of the angiotensin-converting enzyme (ACE) inhibitor monopril and the angiotensin II receptor blocker losartan on serum glucose, protein levels and some serum lipid components were compared in normal and diabetic rats receiving oral antidiabetic drugs 'repaglinide or gliclazide'. The two antihypertensive a...

journal_title：Pharmacological research

authors： el-Batran SA,el-Shenawy SM,Nofal SM,Abdel-Salam OM,Arbid MS

更新日期：2004-08-01 00:00:00

abstract：:Echinomycin, in typical DNA minor groove binder, had comparable efficacy compared to 5-FU in the phase II trail of colon cancer treatment. To improve echinomycin's drawback (hydrophobicity, toxicity), we synthesized the YK-2000 series (echinomycin analogues). Among these, YK-2000 had the best in vitro cytotoxicity on ...

journal_title：Pharmacological research

authors： Park JY,Park SJ,Shim KY,Lee KJ,Kim YB,Kim YH,Kim SK

更新日期：2004-08-01 00:00:00

abstract：:The aqueous extract from aerial parts of Artemisia copa Phil. (Compositae), was evaluated for antinociceptive activity using writhing, formalin, and hot-plate tests in mice. A dose-related antinociceptive response was obtained in the writhing test at doses of 500 and 1000 mg/kg p.o. (percentage of inhibition 23.3 and ...

journal_title：Pharmacological research

authors： Miño J,Moscatelli V,Hnatyszyn O,Gorzalczany S,Acevedo C,Ferraro G

更新日期：2004-07-01 00:00:00

abstract：:The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca(2+) signaling and the activity of Ca(2+)-dependent K(+) channels. The expression of the CYP epoxygenase(s) that generate EETs in endothelial cells is n...

journal_title：Pharmacological research

authors： Fleming I

更新日期：2004-06-01 00:00:00

abstract：:The present study examines the effect of benzyl isothiocyanate (BITC) on uterine contraction in vitro. BITC (10-320 microM) caused irreversible, concentration-dependent inhibition of the spontaneous, prostaglandin F(2alpha) (PGF(2alpha)) and oxytocin-induced force of gravid and non-gravid rat uterine contractions in c...

journal_title：Pharmacological research

authors： Adebiyi A,Adaikan PG,Prasad RN

更新日期：2004-05-01 00:00:00

abstract：:The pharmacokinetics of doxycycline hydrochloride (DoxHcl) at a dose of 5 mg kg-1 BW was studied after an intravenous (i.v.) bolus and intramuscular (i.m.) injections in non lactating goats. A microbiological assay employing Bacillus subtilis as the test organism was used to measure its concentrations in serum and uri...

journal_title：Pharmacological research

authors： Abd El-Aty AM,Goudah A,Zhou HH

更新日期：2004-05-01 00:00:00

abstract：:The DNA microarrays have proven to be a state of the art technique for high throughput comprehensive analysis of thousand of genes in parallel. The application of a DNA microarray to compare normal and pathological cells, tissues or organs may allow, along with classical positional cloning techniques, to speed up the ...

journal_title：Pharmacological research

authors： Meloni R,Khalfallah O,Biguet NF

更新日期：2004-04-01 00:00:00

abstract：:The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250mg/kg per day) or Vitamin C (300mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E...

journal_title：Pharmacological research

authors： Arzi A,Hemmati AA,Razian A

更新日期：2004-03-01 00:00:00

abstract：:The natural resin collected from the trunk wood of Protium heptaphyllum is used in folk medicine to treat inflammatory conditions and to hasten wound repair. In the search of new potential anti-inflammatory agents with gastroprotective property, the present study evaluated its effects in experimental models of gastric...

journal_title：Pharmacological research

authors： Oliveira FA,Vieira-Júnior GM,Chaves MH,Almeida FR,Florêncio MG,Lima RC Jr,Silva RM,Santos FA,Rao VS

更新日期：2004-02-01 00:00:00

abstract：:Chrysin, a natural flavone compound found in plants, has anti-inflammatory activity that has been previously explained in part by the suppression of promoter activities of pro-inflammatory enzymes, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Here we present evidence that several chrysin deriva...

journal_title：Pharmacological research

authors： Cho H,Yun CW,Park WK,Kong JY,Kim KS,Park Y,Lee S,Kim BK

更新日期：2004-01-01 00:00:00

abstract：:The synergistic protective effect of nicorandil (KATP channel opener) and amlodipine (calcium channel blocker) on mitochondrial respiration and mitochondrial lipid contents were examined on isoproterenol-induced myocardial infarction in rats. The rats given isoproterenol (150 mg kg(-1) daily, i.p.) for 2 days showed s...

journal_title：Pharmacological research

authors： Sathish V,Ebenezar KK,Devaki T

更新日期：2003-12-01 00:00:00

abstract：:The aim of this study was to investigate the effects of manganese chloride on gentamicin-induced nephrotoxicity in rats. Thirty-six adult Wistar Albino rats were divided into six equal groups. They were injected with gentamicin sulfate (100 mg kg(-1) per day i.p.) and manganese chloride (2 or 20 mg kg(-1) per day i.p....

journal_title：Pharmacological research

authors： Ateşşahin A,Karahan I,Yilmaz S,Ceribaşi AO,Princci I

更新日期：2003-12-01 00:00:00

abstract：:Perinatal encounter of a hormone and its developing target receptor sets the receptor-hormone-signal transduction complex for life (hormonal imprinting). In this critical period excess of the appropriate hormone or foreign molecules able to bind the receptor can cause faulty imprinting with life-long consequences. At ...

journal_title：Pharmacological research

authors： Csaba G,Kovács P,Pállinger E

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Overexpression of heat shock proteins (Hsps) is associated to myocardial protection and it has been suggested that they could be a marker of cardiac preservation in conditions such as extracorporeal circulation. Aim of this study was to evaluate if cardioplegic arrest can modify the expression of Hsps in the...

journal_title：Pharmacological research

authors： Giannessi D,Caselli C,Vitale RL,Crucean A,Murzi B,Del Ry S,Vanini V,Biagini A

更新日期：2003-11-01 00:00:00

abstract：:The pharmacokinetics of single intravenous and intramuscular administrations and milk antimicrobial equivalent activity of enrofloxacin at a dose of 5 mg per kilogram body weight were studied in clinically healthy lactating goats which were either not treated or had received 7.5 mg per kilogram body weight of albendaz...

journal_title：Pharmacological research

authors： Abo El Sooud K

更新日期：2003-10-01 00:00:00

abstract：:Effect of moclobemide, a selective monoamine oxidase-type A enzyme inhibitor, was investigated on the body temperature of male mice. Moclobemide (15-30 mg kg(-1), i.p.) produced significant reductions of body temperature in both normal and yeast-induced hyperthermic male mice. The hypothermic effect of moclobemide was...

journal_title：Pharmacological research

authors： Ginawi OT

更新日期：2003-09-01 00:00:00

abstract：:In this study, we have investigated the vasodilator response to acetylcholine under diabetic conditions in isolated renal arteries of Wistar rats. The effect of nitric oxide synthase (NOS) inhibition on acetylcholine-induced vasodilator response was investigated. We have also examined the effects of two endothelium-de...

journal_title：Pharmacological research

authors： Yousif MH

更新日期：2003-09-01 00:00:00